Drug Transport across the Blood–Brain Barrier
نویسندگان
چکیده
منابع مشابه
Signaled drug delivery and transport across the blood-brain barrier.
We use a mathematical model to describe the delivery of a drug to a specific region of the brain. The drug is carried by liposomes that can release their cargo by application of focused ultrasound (US). Thereupon, the drug is absorbed through the endothelial cells that line the brain capillaries and form the physiologically important blood-brain barrier (BBB). We present a compartmental model o...
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Medical treatment options for central nervous system (CNS) diseases are limited due to the inability of most therapeutic agents to penetrate the blood-brain barrier (BBB). Although a variety of approaches have been investigated to open the BBB for facilitation of drug delivery, none has achieved clinical applicability. Mounting evidence suggests that ultrasound in combination with microbubbles ...
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THE ORIGINAL idea of a blood-brain barrier arose at the turn of the century as an explanation of the properties of the living brain in relation to certain dyes and pharmacologically active compounds, injected either into the bloodstream or directly into the cerebrospinal fluid (CSF) of experimental animals (reviewed by Bradbury, 1979). This developed into the general concept of a cellular barri...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2012
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.2012.126